Honey’s therapeutic value has been described in the world’s earliest medical literature, and it has been known to possess antibacterial and wound-healing properties since ancient times. Honey’s healing properties are related to its antibacterial properties, ability to keep wounds moist, and high viscosity, which help to build a protective barrier against infection.

Its immunomodulatory properties are also important for wound healing. Most honeys have antibacterial properties due to the enzymatic generation of hydrogen peroxide. Its mechanism could be linked to honey’s low pH and high sugar content (high osmolarity), both of which are sufficient to prevent microbial development.

Honey is a potent antibacterial with a diverse set of properties. The sugar content, phenolic chemicals, hydrogen peroxide, 1, 2-dicarbonyl compounds, and bee defensin-1 all contribute to honey’s antibacterial activity. Depending on the nectar source, bee type, and storage, all of these components are present in varying amounts. These components interact together to make honey effective against a wide range of pathogens, including multidrug-resistant bacteria, and to control their antimicrobial resistance.

Honey’s usefulness and potency against microorganisms is determined by the type of honey produce, which is determined by its botanical origin, bee health, provenance, and processing method. Antibiotics combined with honey had a higher antibacterial activity, and synergistic actions against biofilms were seen. Honey has been used in the treatment of surface wounds, burns, and inflammation in medicine, and when combined with antibiotics, it has a synergistic effect.

Honey’s low pH (3.5–4) promotes tissue regeneration by reducing protease activity at the wound site, increasing oxygen release from haemoglobin, and promoting fibroblast and macrophage activity. H2O2 is also antibacterial, disinfecting the wound site and stimulating the generation of vascular endothelial growth factor. Buy natural honey online from Naturekart to removes free radicals from wounds and burns while also reducing scarring and contractures. Honey’s anti-inflammatory and antibacterial properties will keep the damaged region wet, preventing fibrosis and degeneration. Honey is an excellent choice for plastic surgery since it promotes quick healing and reduces scars.

Honey protects skin maceration because of its high osmolarity and ability to keep the damage wet. Honey reduced pain and inflammation even in non-infected areas. Honey’s use in medical contexts has decreased economic loss and offered proved economic benefits by cutting direct expenses in contrast to traditional therapies, using fewer antibiotics, and requiring less hospitalisation time. The purpose of this review is to give an overview of honey’s antibacterial properties and applications.

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